Email: ute.kothe@uleth.ca
Webpage: http://scholar.ulethbridge.ca/kothe
Biochemistry of ribosome biogenesis and tRNA maturation


Recent Publications:
- Tillault, A.S., Fourmann, J.B., Loegler, C., Wieden, H.-J., Kothe, U., and Charpentier, B., (2015) Contribution of two conserved histidines to the dual activity of archaeal RNA guide-dependent and -independent pseudouridine synthase Cbf5. RNA 21, 1233-1239 DOI: 10.1261/rna.051425.115 (Impact Factor: 4.622)
- Friedt, J., Leavens, F.M., Mercier, E., Wieden, H.-J., and Kothe, U. (2014) An arginine-aspartate network in the active site of bacterial TruB is critical for catalysing pseudouridine formation. Nucleic Acids Research, 42, 3857 - 3870 (IF: 8.808)
- Kamalampeta, R., Keffer-Wilkes, L.C., and Kothe, U. (2013) tRNA binding, positioning and modification by the pseudouridine synthase Pus10. J. Mol. Biol., 425(20), 3863-3874 (IF: 3.959)
- Kamalampeta, R., and Kothe, U. (2012) Archaeal proteins Nop10 and Gar1 increase the catalytic activity of Cbf5 in pseudouridylating tRNA. Scientific Reports, 2: 663, DOI: 10.1038/srep00663 (IF: 5.578)
- Kothe, U. (2012) New frontiers in studying pseudouridine formation in RNA. Cell News (DGZ Journal) 2/2012, 48-56 (invited review)
- Wright, J.R., Keffer-Wilkes, L.C., Dobing, S.R., and Kothe, U. (2011) Pre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA and RluA reveals uniformly slow catalysis. RNA, 17, 2074-2084 (IF: 4.622)
- Kothe, U. (2010) Recent Progress on Understanding Ribosomal Protein Synthesis. In Comprehensive Natural Products II Chemistry and Biology, Section Amino Acids, Peptides and Proteins, Elsevier: Oxford, UK, 2010, Volume 5, 353-382 (invited)
Group members (Fall 2016)
- Dr. Anne Rintala-Dempsey (Research Associate)
- Dr. Anne-Sophie Tillault (PDF)
- Dr. Govardhan Reddy Veerareddygari (PDF)
- Evan Caton (PhD student)
- Abeer Ogailan (MSc student)
- Sarah Schultz (MSc student)
- Dominic Czekay (MSc student)
- Erin Kelly (Undergraduate)
- Elijah Dueck (Undergraduate)
- Lindey Felske (Undergraduate)
- Emily Soon (Research Technician)
Former Lab Members
- Laura Keffer-Wilkes (PhD student - Summer 2012 - Summer 2016)
- Jessica Baedke (Undergraduate - Summer 2016)
- Alycia Amatto (Undergraduate - Summer 2015; AIHS Summer Studentship)
- Elijah Dueck (Undergraduate - Summer 2015; NSERC USRA)
- Jordan Stewart (Undergraduate - Spring 2015)
- Kody Beler (Undergraduate - Spring 2015)
- Dominic Czekay (Undergraduate - Fall 2014)
- Erin Kelly (Undergraduate - Fall 2014)
- Jan Tuescher (Undergraduate - Fall 2014)
- Melanie Schwerdtfeger (Undergraduate - German Exchange Summer/Fall 2014)
- Elijah Dueck (Undergraduate - Summer 2014; NSERC USRA)
- Alycia Amatto (Undergraduate - Summer 2014; AIHS Summer Studentship)
- Dominic Czekay (Undergraduate - Summer 2014; Chinook Summer Research Award)
- Tim Vos (Undergraduate - Summer 2014)
- Sally Xu (HYRS - Summer 2014)
- Chris Cote (Undergraduate Fall 2013/Spring 2014)
- Suneet Kharey (Undergraduate Fall 2013)
- Saskia Funk (RISE - German Exchange Summer/Fall 2013)
- Jenna Friedt (MSc Student - Fall 2011 - Summer 2013)
- Rajashekhar Kamalampeta (PhD Student - Fall 2008 - Spring 2012)
- Justin Luu (undergraduate)
Some Recent Successes:
- 2015 RiboWest Poster Awards to Jessica Baedke (Undergraduate) and Sarah Schultz (Undergraduate)
- Ute Kothe awarded Tier II Strategic Chair in Transcriptomics of RNA modification by AITF (2015-2019)
- CIHR Synapse Mentorship Award 2012 - Individual Researcher, $ 5,000, for Ute Kothe in recognition of science outreach activities and organizing RiboWest Conferences
- Poster award at RiboWest conference for Jenna Friedt
- 1st Presentation Award for graduate students in Biochemistry for Jenna Friedt at 6th annual Chinook Symposium for Chemistry & Biochemistry 2012
- Loren Hepler Gold Medal for PhD Research Excellence, second place, for Laura Keffer-Wilkes at 6th annual Chinook Symposium for Chemistry & Biochemistry 2012