2017 - Dr. Lewis Kay

The Alberta RNA Research and Training Institute (ARRTI) is delighted to host this year's Canada Gairdner International Award recipient Dr. Lewis Kay. Dr. Kay was awarded the 2017 Canada Gairdner International Award "for the development of modern NMR spectroscopy for studies of biomolecular structure dynamics and function, including applications to molecular machines and rare protein conformations".

ARRTI invites all interested parties to the 11th Annual Chinook Symposium for Chemistry and Biochemistry on October 20, 2017.

The Symposium will begin with Dr. Lewis Kay's keynote lecture titled:

"NMR Why Bother? Studies of the p97 Molecular Machine Provide an Answer"

Date: Thursday, October 19th, 2017

The Work:

Professor Kay and his coworkers have made important contributions to the field of biomolecular nuclear magnetic resonance (NMR) spectroscopy, with the development of methods that are used to 'visualize' protein molecules in their natural solution environment and to obtain information about how their shapes evolve in time, leading to biological function.  These methods have shed light on how molecules involved in neurodegeneration can form abnormal structures that ultimately lead to diseased states.  In addition, his work has extended our understanding of how cellular machines function and how the communication between different parts of these machines can be targeted for the development of drugs in the fights against certain cancers.

The Impact:

His research has expanded our understanding of the flexible nature of protein structure and the important of flexibility in both function and malfunction.  This, in turn, has led to new insights into what the key regions of molecules might be for drug targeting.  The methods developed by Dr. Kay are used in labs around the world, including those researching illnesses such as diabetes, cancer and cardiovascular disease.  The tools developed by his research group are disseminated freely and are extensively used worldwide.