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Join the School of Graduate Studies & Office of Postdoctoral Research for the first talk in our summer lecture series. We are excited to welcome Dr. M. Quadir Siddiqui, postdoctoral fellow in the Laboratory of Medicinal Biophysics and part of Trushar Patel’s research group.
All coffee breaks will begin with a 30-minute talk by a ULethbridge postdoc, followed by 15-minute Q&A session, and a 45-minute coffee break. Learn about the exciting research being done by our amazing postdoc community and forge new research connections within & beyond your department. No RSVP needed & all are welcome. While these events are targeted towards postdocs & graduate students, all members of the ULeth community are invited and encouraged to attend.
Title:
On the development of prostate cancer: an investigation into the role of zyxin, a DNA binding protein
Abstract:
Human zyxin is part of a protein complex involved in how cells attach to and interact with each other. Despite being identified more than 30 years ago, the function of zyxin remains mostly unknown.
Using prostate cancer cells as a model, our research has shown that zyxin binds cellular DNA directly, leading to a cascade of events that impact regulation of the cell cycle and cell death. Our work demonstrates that zyxin interacts directly with nonfunctional stretches of DNA called pseudogenes and helps to regulate the function of mitochondria. Learning more about the role zyxin plays in these cellular events may have benefits in our understanding of the development and treatment of prostrate cancer, and possibly other types of cancer.
Contact:
Deborah Fox | deborah.fox@uleth.ca