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The Department of Chemistry & Biochemistry Presents:
Dr. Stephen Rader
Department of Chemistry
University of Northern British Columbia
Spliceopathies: Building a Foundation for Tomorrow's Cures
Thursday, Nov. 27, 2014
12:15 – 1:30pm
C640, UHall
All are Welcome
Abstract:
It has been estimated that over 60% of disease-causing mutations exert their effects via disruption of pre-mRNA splicing, the essential process whereby non-coding regions are removed from messenger RNA prior to its translation into proteins. Spliceopathies therefore present a broad range of targets for medical intervention, making a detailed understanding of the splicing process essential. Progress in understanding splicing has been slowed by the inordinate complexity of the splicing machinery (over 200 proteins in humans).
I will describe our biochemical and biophysical investigations of the splicing mechanism, as well as our recent discovery of a far simpler splicing system consisting of only ~40 core proteins. This system promises to facilitate studies of splicing, thereby opening up new avenues of research into cures for spliceopathies.
Contact:
Susan Hill | susan.hill@uleth.ca | (403) 329-2301