Ute Kothe



  • Kelly, E.K., Czekay, D.P., and Kothe U.* (2019) Base pairing interactions between substrate RNA and H/ACA guide RNA modulate the kinetics of pseudouridylation, but not the affinity of substrate binding by H/ACA small nucleolar ribonucleoproteins. RNA. DOI: 10.1261/rna.071043.119 (IF: 4.94)


  • Tillault, A.-S.Schultz, S.K.Wieden, H.-J., and Kothe, U.* (2018) Molecular determinants for 23S rRNA recognition and modification by the E. coli pseudouridine synthase RluE. J. Mol. Biol. 430(9): 1284-1294. DOI: 10.1016/j.jmb.2018.03.011 (IF: 4.632)


  • Caton, E.A., Kelly, E.K., Kamalampeta, R., and Kothe, U. (2017) Efficient RNA pseudouridylation by eukaryotic H/ACA ribonucleoproteins requires high affinity binding and correct positioning of guide RNA. Nucleic Acids Res. In Press. DOI: 10.1093/nar/gkx1167 (IF: 10.162)
  • Rintala-Dempsey, A.C. and Kothe, U. (2017) Eukaryotic stand-alone pseudouridine synthases – RNA modifying enzymes and emerging regulators of gene expression? RNA Biol: 1-12. DOI: 10.1080/15476286.2016.1276150 (IF: 4.076)


  • Keffer-Wilkes, L.C., Veerareddygari, G.R., and Kothe, U. (2016) RNA modification enzyme TruB is a tRNA chaperone. PNAS 113(50): 14306-11. DOI: 10.1073/pnas.1607512113 (IF: 9.423)


  • Tillault, A.S., Fourmann, J.B., Loegler, C., Wieden, H.-J., Kothe, U., and Charpentier, B. (2015) Contribution of two conserved histidines to the dual activity of archaeal RNA guide-dependent and -independent pseudouridine synthase Cbf5. RNA 21: 1233-9. DOI: 10.1261/rna.051425.115 (IF: 4.622)


  • Friedt, J., Leavens, F.M., Mercier, E., Wieden, H.-J., Kothe, U. (2014) An arginine-aspartate network in the active site of bacterial TruB is critical for catalyzing pseudouridine formation. Nucleic Acids Res. 42: 3857-70. DOI: 10.1093/nar/gkt1331 (IF: 8.808)


  • Kamalampeta, R., Keffer-Wilkes, L.C., and Kothe, U. (2013) tRNA binding, positioning and modification by the pseudouridine synthase Pus10. J. Mol. Biol., 425(20): 3863-74. DOI: 10.1016/j.jmb.2013.05.022 (IF: 3.959)


  • Kamalampeta, R., and Kothe, U. (2012) Archaeal proteins Nop10 and Gar1 increase the catalytic activity of Cbf5 in pseudouridylating tRNA. Sci. Rep. 2: 663. DOI: 10.1038/srep00663 (IF: 5.578)
  • Kothe, U. (2012) New frontiers in studying pseudouridine formation in RNA. Cell News (DGZ Journal) 2/2012, 48-56 (invited review)


  • Wright, J.R., Keffer-Wilkes, L.C., Dobing, S.R., and Kothe, U. (2011) Pre-steady-state kinetic analysis of the three Escherichia coli pseudouridine synthases TruB, TruA and RluA reveals uniformly slow catalysis. RNA 17: 2074-84. DOI: 10.1261/rna.2905811 (IF: 4.622)


  • Kothe, U. (2010) Recent Progress on Understanding Ribosomal Protein Synthesis. In Comprehensive Natural Products II Chemistry and Biology, Section Amino Acids, Peptides and Proteins, Elsevier: Oxford, UK, 2010, Volume 5, 353-382