Patel Group

Email: trushar.patel@uleth.ca

Website: www.trpatel.com

Research Interests:

Biomolecular Interactions: The unifying theme of my research is to study multi-domain proteins, protein-protein and protein-nucleic acids complexes that affect various cellular processes.

Host Protein - Viral RNA Interactions

Viruses require host machinery to replicate and propagate. Although our immune system has several layers of defense mechanisms, often viral infection results in hijacking host cell machinery. A variety of host proteins recognize viral RNA molecules as a part of an innate immune system. On the other hand, in some cases viral RNA recognize and employ host proteins to facilitate their replication and propogation. The main focus of our group is to understand in fine detail how viral components recognize DEAD-box helicases (e.g. DDX1, DDX3 and DDX5) and develop novel inhibitors to interfere with host-viral component interactions and therefore inhibit viral replication using a multidisciplinary approach.

West Nile Virus 3’ UTR – OAS1 complex, PubMed:25871524

 

Adenovirus VAI – PKR complex, PubMed: 24291322

Group Members (Fall 2018)

  1. Vanessa Meier-Stephenson, MD, PhD (Postdoctoral fellow)
  2. Tyler Mrozowich (MSc Student)
  3. Darren Gemmill (MSc Student)
  4. Simmone D'souza (Undergraduate)
  5. Corey Nelson (Undergraduate)

Former Group Members

  • Alisha Merchant (Undergraduate, Summer 2018)
  • Jason Schacher (Undergraduate, Summer 2018)
  • Corbyn Pilling (Undergraduate, Summer 2018)
  • Jeremy Quiroga (Undergraduate, Spring - Summer 2017)
  • Sunil Stephenson (Undergraduate, Spring 2017)